Kasper joins Tune Pers (@tunepers) at @UCPH_BRIDGE postdocs and @Metabolcenter to discuss cell-type-specific proteomes and agnostic genetically-guided tools to map mechanisms underlying complex traits and diseases.
Kasper discusses translational genetics with the industry at HMS
Kasper joins Sally John, director of translational biology at Biogen, for a conversation about Translational Genetics in Neuroscience, hosted by the Harvard Brain Initiative and the Arlotta Lab.
Frederik Lassen starts his PhD at the University of Oxford
Frederik Lassen moves to Oxford, UK, to start a PhD program at the Wellcome Centre for Human Genetics. He will continue collaborating with the Lage Lab and we wish him the best of luck in his new scientific endeavors!
Joshua Ching joins the Lage team in an undergraduate program
Joshua Ching joins the Lage group as part of MIT’s Undergraduate Research Opportunities Program (UROP). He will bring a much appreciated data analysis component to our efforts and will collaborate with senior members in the group. Welcome to the Lage team, Joshua!
Yu-Han’s paper on characterizing the obesity metabolome published in International Journal of Obesity
Yu-Han and colleagues combined untargeted metabolomics with genetics to identify metabolites that may be causes or effects of obesity. They further grouped these metabolites into pathways to highlight how distinct biological mechanisms may be involved in obesity. Their findings demonstrate the strong potential of using untargeted metabolomics and genetically informed causal inference (Mendelian randomization) to uncover causal biological connections between metabolites and various human diseases, especially as larger datasets with both genotype and metabolite profiling data become available in the future. Congratulations on the great work, Yu-Han!
Kasper contributes his expertise in data communication to the COVID19 response
Kasper joins the Danish national discussion about transparency & openness of the COVID19 models & data in an important effort led by the Danish Prime Minister, Mette Frederiksen, to better communicate COVID19-related information to the public.
Genoppi is a preprint on bioRxiv
Our study co-led by @gretapinta, @flassen_, @yuhanhsu and @mjapkim, ‘Genoppi: an open-source software for robust and standardized integration of proteomic and genetic data’, is now posted as a pre-print on bioRxiv. Genoppi allows the seamless integration of proteomic data with genetic information from a multitude of public or custom gene lists to maximize the interpretation of protein interaction datasets.
Cancer network algorithm led by Heiko Horn accepted to ISMB
The cancer network algorithm paper titled “Prediction of cancer driver genes through network-based moment propagation of mutation scores” has been accepted for presentation at ISMB 2020 and for inclusion in the conference proceedings. This work is in collaboration with Karsten Borgwardt and led by Heiko Horn and Anja Gumpinger.
Kasper presents BINe project to Open Targets community
Kasper presented the Stanley Center Brain Interaction Network project to the Open Targets Community. Great job Kasper!
Kasper interviewed by Vivien Marx for benchmarking OMICS software tools
Kasper recently interviewed with Vivien Marx on her Nature Methods Technology Feature titled ‘Bench pressing with genomics benchmarkers,’ which highlights the importance of benchmarking for genomics softwares. The insightful article can be found here: https://www.nature.com/articles/s41592-020-0768-1?proof=trueatural-gas-cut-pollution-saved-lives%2F