The Lage Lab uses genomic and computational approaches to gain mechanistic insights into diseases of major public health significance in order to lay the foundation for rationally designed medicines. This is achieved through generating cell-type-specific, multi-comic datasets, developing computational technologies to analyze them, and performing functional follow-up assays to elucidate the mechanisms that are perturbed in complex disorders such as metabolic diseases, psychiatric disorders, and cancers. The developed tools and data are made available to the scientific community in a bid to accelerate the understanding and treatment of complex diseases.