Yu-Han and colleagues combined untargeted metabolomics with genetics to identify metabolites that may be causes or effects of obesity. They further grouped these metabolites into pathways to highlight how distinct biological mechanisms may be involved in obesity. Their findings demonstrate the strong potential of using untargeted metabolomics and genetically informed causal inference (Mendelian randomization) to uncover causal biological connections between metabolites and various human diseases, especially as larger datasets with both genotype and metabolite profiling data become available in the future. Congratulations on the great work, Yu-Han!
Yu-Han’s paper on characterizing the obesity metabolome published in International Journal of Obesity
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