General

Email lage.kasper@mgh.harvard.edu and klagelab@gmail.com with a CV and cover letter if you are interested in hearing more about our lab or job opportunities. You could also apply directly to the job postings below.

Job opportunities

Computational Postdoctoral Associate

Job Description

The Lage Lab at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is seeking a self-motivated, skilled postdoctoral associate with a Ph.D. in the fields of computational biology, statistical genetics, and/or common genetic traits to study the genetic mechanisms of metabolic diseases at an unprecedented scale and resolution. The Lage group develops and applies computational technologies to functionally interpret large genomic datasets and to understand how genetic variation results in common genetic diseases. 

The successful applicant will join an interdisciplinary team and will collaborate with the Engreitz and Claussnitzer groups and others to identify key biological processes in multi-dimensional (transcriptomic, epigenetic, proteomic) datasets and relate them to disease. The candidate will work closely with molecular biologists in the lab to help relate data analyses to known biological principles in human cell lines.

This position offers an exciting opportunity to become involved in the age of biological “big data” and to contribute to the current revolution in our biological understanding of debilitating, genetic diseases. The Broad Institute provides a vibrant research environment with close links to MIT, Harvard and the Harvard-affiliated hospitals across Boston. Being a member of our team will provide the opportunity for your contributions to be utilized and recognized across the vast global network of genomic research.

Qualified candidates should have:

  • A Ph.D. in Human Genetics, Statistical Genetics, Computer Science, Bioinformatics, Biostatistics, Biology, or a related field.
  • Proficiency with programming and scripting languages appropriate for scalable data analysis (e.g., Python, R, Unix, or the likes).
  • Experience with biological data analysis (experience with genetics and/or proteomics data is a plus).
  • Experience in the fields of common genetic diseases and/or obesity/diabetes is a plus.
  • Excellent oral and written communication skills.
  • Creative, highly motivated, independent.
  • Ability to work with both computational and experimental scientists in a multidisciplinary team.
  • Ability and will to drive and lead a project.

Characteristic duties:

  • Work with experimental scientists and research associates to optimize the design of sequencing and proteomic experiments.
  • Perform high-dimensional data analysis for single-cell and bulk RNA-sequencing, CUT&RUN sequencing and whole cell and targeted proteomic data.
  • Integrate multi-modal datasets to infer gene regulatory networks and genetically informed cellular programs.
  • Adapt and expand computational and theoretical capabilities into new applications and identify new research directions.
  • Train and mentor junior lab members.
  • Make significant contributions to the content and writing of scientific papers and presentations.
  • Contribute to generation of computational models.

The Broad Institute is an amazing place to do research that makes a difference in the lives of patients. Come join us!

#LI-DNP

All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021.  Requests for exemption for medical or sincerely held religious beliefs will be considered.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Experimental Postdoctoral Associate

Job Description

The Lage Lab at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is seeking a self-motivated, skilled postdoctoral associate with a Ph.D. in the fields of biochemistry and/or molecular, cell and developmental biology to study the genetic mechanisms of metabolic diseases at an unprecedented scale and resolution. The Lage group develops and applies computational technologies to functionally interpret large genomic datasets and to understand how genetic variation results in common genetic diseases. As part of the new Center, the postdoctoral associate will generate data to contribute to building the Human Gene Regulatory Map and gain insights into the genetic perturbations leading to metabolic disease.

The successful applicant will join an interdisciplinary team and will collaborate with the Engreitz and Claussnitzer groups and others to identify key biological processes in multi-dimensional (transcriptomic, epigenetic, proteomic) datasets and relate them to disease. The candidate will work closely with computational biologists to help relate data analyses to known biological principles in human cell lines.

This position offers an exciting opportunity to become involved in the age of biological “big data” and to contribute to the current revolution in our biological understanding of debilitating, genetic diseases. The Broad Institute provides a vibrant research environment with close links to MIT, Harvard and the Harvard-affiliated hospitals across Boston. Being a member of our team will provide the opportunity for your contributions to be utilized and recognized across the vast global network of genomic research.

Qualified candidates should have:

  • A Ph.D. in Biochemistry, Molecular, Cell and Developmental Biology, or a related field.
  • Demonstrated track record of productivity within fast-paced, cross-disciplinary and collaborative research environments.
  • Hands-on experience developing and characterizing human iPSC-based in vitro models.
  • Extensive experience with most common molecular biology techniques and biochemistry.
  • Familiarity with the background and concepts of common polygenic disease risk.
  • Knowledge of current genome editing techniques and their application to neuron cell lines.
  • Excellent oral and written communication skills.
  • Ability and will to drive and lead a project in a multidisciplinary team.

Characteristic duties:

  • Work with computational scientists in the design of transcriptomic, epigenomic and proteomic experiments.
  • Produce different specialized cell types from human stem cells.
  • Adapt and expand protocols to the use of different human cell lines.
  • Generate single-cell and bulk RNA-sequencing, CUT&RUN sequencing and whole cell and targeted proteomic data in various cell types.
  • Identify needs for and carry out experimental validations of sequencing and proteomic results.
  • Conceptualize and communicate new research directions emerging from initial results.
  • Train and mentor junior lab members.
  • Make significant contributions to the content and writing of scientific papers and presentations.

The Broad Institute is an amazing place to do research that makes a difference in the lives of patients. Come join us!

#LI-DNP

All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021.  Requests for exemption for medical or sincerely held religious beliefs will be considered.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

More job opportunities in the the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease are listed here.