Schizophrenia PPI paper published in iScience

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Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia‘ has been published in iScience.

In this study, we performed interaction proteomics for 6 schizophrenia risk genes prioritized from GWAS loci in human induced excitatory neurons. The resulting protein-protein interaction network is enriched for common variant risk of schizophrenia across both European and East Asian ancestries and can complement fine-mapping and eQTL data to prioritize genes in GWAS loci. We observed convergent genetic signals in the HCN1 sub-network, which is enriched for common variant risk of schizophrenia and contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in individuals with schizophrenia and bipolar disorder. Our findings in this study (and the sister study on autism spectrum disorders) showcase brain cell-type-specific protein interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in neuropsychiatric disorders.

Greta presents the BINe projects at WCPG 2021

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At this year’s World Congress of Psychiatric Genetics, Greta presented a talk titled “Combining Proteomics and Genetics to Elucidate the Molecular Mechanisms Underlying Neurodevelopmental and Neuropsychiatric Diseases in Human Neurons”. In this presentation, Greta highlighted the BINe projects in which we combined neuroscience, genetics, and proteomics approaches to understand schizophrenia and ASD.

Kasper is the managing director of the new Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at Broad Institute

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The Novo Nordisk Foundation and Broad Institute of MIT and Harvard are launching a new research Center for Genomic Mechanisms of Disease, an initiative that will accelerate efforts to mine genetic data for insights into disease mechanisms – and eventually rationally designed treatments.

Supported by a $47.5 million commitment from the Novo Nordisk Foundation, the Center will facilitate close collaborations between the Broad Institute and Danish researchers investigating the genetics and gene regulation of common complex disease, with an initial focus on type 2 diabetes and obesity. The Center will align with existing international efforts, data sharing, methodology, and tools to contribute to the roadmap of the International Common Disease Alliance, and working in common cause with investigators from other large-scale efforts such as the Accelerating Medicines Partnership in Common Metabolic Diseases and the Impact of Genomic Variation on Function consortia.

The research collaboration of the Center aims to advance patient-centered research and precision medicine. The Center will establish an exchange program to provide opportunities for Danish scientists to study genomic technologies at the Broad Institute. In turn, these collaborations will catalyze and contribute to expanding biomedical research in Denmark. The new Center will be directed by Kasper, who has played an important role in the planning and development of the initiative since it was conceived in 2019. His whole team is particularly excited and proud to be part of this exceptional research opportunity!

We are hiring!

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We are hiring for several positions. Email with a CV and cover letter if you are interested in hearing about our openings.

Polygenic risk score paper published in Nature Communications

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โ€˜Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk predictionโ€™ has been published in Nature Communications. This paper describes a machine learning method (MCCP) that can be used to estimate personalized confidence levels of disease risk prediction based on polygenic risk scores, thereby enhancing their utility and interpretability in clinical settings.

Coexpression network paper published in Nature Neuroscience

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โ€˜Coexpression network architecture reveals the brain-wide and multiregional bias of disease susceptibilityโ€™, a collaborative project with the Geschwind Lab at UCLA and the Battle Lab at Johns Hopkins, has been published in Nature Neuroscience. In this project, we created an atlas of human brain coexpression networks using RNA-seq data from the GTEx project, and used this resource to understand convergent pathways and brain regions affected by disease-associated variation in the adult brain. The generated networks can be explored in a web browser hosted by the Geschwind Lab.