‘Coexpression network architecture reveals the brain-wide and multiregional bias of disease susceptibility’, a collaborative project with the Geschwind Lab at UCLA and the Battle Lab at Johns Hopkins, has been published in Nature Neuroscience. In this project, we created an atlas of human brain coexpression networks using RNA-seq data from the GTEx project, and used this resource to understand convergent pathways and brain regions affected by disease-associated variation in the adult brain. The generated networks can be explored in a web browser hosted by the Geschwind Lab.

Our research associate II, @JacquiMMartn1 is off to the next milestone in her scientific career, the start of a MD/PhD program on full scholarship at UCLA. We are so proud of you!

We are happy to welcome Julia Biagini as a new research associate II on our team. Julia will be joining @gretapinta in the lab to work on the differentiation of human neurons and the many downstream experiments that help us understand the biological mechanisms that are dysfunctional in neuropsychiatric disorders. Welcome to the Lage family, Julia!

‘Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data’ is accepted for publication at Nature Communications! The Lage team produced a user-friendly, open-source software that allows its users to see beyond their proteomic datasets by identifying cell/tissue-specific patterns and importantly, converging proteomic and genetic data in order to identify a vast diversity of disease signatures. Fantastic work by @gretapinta, @flassen_, @yuhanhsu, @mjapkim, @JacquiMMartn1 and colleagues.

The Lage team has barely slowed down during the pandemic as evidenced by the mass production of 1.2 billion human excitatory neurons by @gretapinta and @JacquiMMartn1 to study the biological mechanisms that are affected in neuropsychiatric disease.

During the Stanley Center Program Meeting this week, Yu-Han and Frederik presented an overview of Genoppi and gave a live demo to illustrate how it can facilitate QC and analysis of quantitative proteomic data. Greta gave an update on the BINe-ASD project, in which we generated protein-protein interaction networks of autism risk genes in human induced neurons to uncover biological mechanisms and pathways underlying these genes.

Yu-Han completed her two-year post-doctoral fellowship in the Harvard T32 Training Program in Bioinformatics Applied to Diabetes, Obesity and Metabolism. For the first part of her fellowship, she worked on a project that combined human genetics and untargeted metaoblomics to infer causal relationships in the obesity metabolome in the Hirschhorn Lab. After joining Lage Lab, she contributed to our efforts in using cell-type-specific protein-protein interaction data to study complex diseases such as schizophrenia, autism, type 2 diabetes, and myocardial infarction. Yu-Han is looking forward to continuing these exciting projects in our group after the end of her fellowship!

Fatma’s paper titled ‘Systematic auditing is essential to debiasing machine learning in biology’ has been published in Communications Biology. In this work, we developed a systematic auditing framework to uncover biases in three machine learning applications of therapeutic interest, and provided guidelines for tailoring this framework to other biomedical applications. Great work by Fatma, Nadine, and colleagues!

The Lage Lab is awarded a Collaborative Grant by the Lundbeck Foundation together with @thomas_werge, at the Institute for Biological Psychiatry, and @Kirkeby_Lab, at the University of Copenhagen. As a consortium, we will tackle the discovery of cellular mechanisms that are compromised in patients with schizophrenia. At a time when mental illness is raising growing awareness, our research will inform the much-needed discovery of new therapies to treat mental disorders.

Kasper contributes to Cell Systems’ Voices, a piece on Leadership in cross-disciplinary research environments, where he explains that a key component of a lab’s success and positive mentorship is achieved through maintaining and encouraging communication.