Kasper and group presents at the annual meeting of the Scientific Advisory Board of the Stanley Center for Psychiatric Research at the Broad Institute

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The Lage Lab and collaborators presented one talk and eight posters at the 2017 Annual Meeting of the Scientific Advisory Board of the Stanley Center

Talk

From models to mechanism: Neuronal protein networks perturbed by genetics in psychiatric diseases – Kasper Lage

Posters

#6. A unified web platform for network-based analyses of genomic data
Taibo Li, Johnathan Mercer, Joseph Rosenbluh, April Kim, Heiko Horn, Liraz Greenfeld, David An, Andrew Zimmer, Arthur Liberzon, Jon Bistline, Ted Natoli, Yang Li, Aviad Tsherniak, Rajiv Narayan, Aravind Subramanian, Ted Liefeld, Bang Wong, Dawn Thompson, Sarah Calvo, Steve Carr, Jesse Boehm, Jake Jaffe, Jill Mesirov, Nir Hacohen, Aviv Regev, Kasper Lage

#7. A scored human protein-protein interaction network to catalyze genomic interpretation
Taibo Li, Rasmus Wernersson, Rasmus B Hansen, Heiko Horn, Johnathan Mercer, Greg Slodkowicz, Christopher T Workman, Olga Rigina, Kristoffer Rapacki, Hans H Stærfeldt, Søren Brunak, Thomas S Jensen, Kasper Lage

SAB_2017_TL
Taibo Li presenting his poster

#11. Complementary approaches for at scale generation of human neuronal material for proteomic analyses
Eugeniu Nacu, William Crotty, Alison O’Neil, Francesca, Rapino, Natalie Petrossian, Benjamin Tanenbaum, Edyta Malolepsza, April Kim, Monica Schenone, Jake Jaffe, Lee Rubin, Kasper Lage, Kevin Eggan

#12. Overview of human brain networks perturbed by genetics in psychiatric disorders
Edyta Malolepsza, Eugeniu Nacu, Natalie Petrossian, William Crotty, April Kim, Taibo Li, Benjamin Tanenbaum, Stephan Ripke, Taibo Li, Mark Daly, Kiki Lilliehook, Jake Jaffe, Monica Schenone, Kevin Eggan, Kasper Lage

#13. Time course analysis of CACNA1C protein interaction partners
Eugeniu Nacu, Edyta Małolepsza, April Kim, Taibo Li, Natalie Petrossian, Benjamin Tanenbaum, William Crotty, Stephan Ripke, Mark Daly, Kiki Lilliehook, Monica Schenone, Jake Jaffe, Kevin Eggan, Kasper Lage

SAB_2017_collab

#14. Genoppi: a web application for interactive integration of experimental proteomics results with genetic datasets
April Kim, Edyta Małolepsza, Justin Lim, Kasper Lage

#15. Bayesian multivariate analysis of RNA seq data to identify specific protein-protein interactions of the brain
Sandrine Muller, Taibo Li, April Kim, Edyta Małolepsza and Kasper Lage.

SAB_2017_SM
Sandrine Muller presenting her poster

#16. BINe: selecting index genes for proteomics experiments and determining brain-relevant isoforms
April Kim, Taibo Li, Stephan Ripke, Eugene Nacu, Olli Pietilainen, Mark Daly, Kevin Eggan, Kasper Lage

Jakob Jespersen invited to present his work at the Broad Institute Stanley Center Online Journal Club

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Organizer Dennis Lal.

Location: Broad Institute at  Ames St 75A, floor 09, room Glacier-9031.  

Online information: https://sites.google.com/broadinstitute.com/onlinejournalclub

Presentations available on youtube: tinyurl.com/zop6zze 

Title: “How protein structures can help interpret missense variants”

Follow Jakob on Twitter: @JakobBerg_

Taibo Li invited to present his work at the Broad Institute Stanley Center Online Journal Club

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Organizer Dennis Lal.

Location: Broad Institute at  Ames St 75A, floor 09, room Glacier-9031.  

Online information: https://sites.google.com/broadinstitute.com/onlinejournalclub

Presentations available on youtube: tinyurl.com/zop6zze 

Paper: A scored human protein-protein interaction network to catalyze genomic interpretation   

Link to the paper: http://www.nature.com/nmeth/journal/v14/n1/full/nmeth.4083.html 

Follow Taibo on Twitter: @taibo_li

Lage Lab joins the NIH Accelerating Medicines Partnership in type 2 diabetes

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We’re happy to announce that Kasper Lage joined the National Institutes of Health Accelerating Medicines Partnership in type 2 diabetes to work on cell-type-specific protein networks involved in type 2 diabetes together with Jose Florez, Chad Cowan, Mark McCarthy, Anna Gloyn and Rob Sladek.

For more information about the NIH Accelerating Medicines Partnership: click here.

For more information about Anna Gloyn: click here.

For more information about Chad Cowan: click here.

For more information about Mark McCarthy: click here.

For more information about Jose Florez: click here.

For more information about Rob Sladek: click here.

 

Lage Lab is awarded significant grant from the Lundbeck Foundation to study psychiatric diseases

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We’re delighted to announce that the Lage Lab has been awarded a three year grant from the Lundbeck Foundation to study the protein networks perturbed by genetics in psychiatric diseases. This project will enable us to strengthen our current experimental work in the Stanley Center for Psychiatric Research at the Broad Institute and is a collaboration with the Danish iPSYCH consortium. The grant will furthermore support training of Danish postdocs in the Lage Lab and at the Broad Institute.

 

For more information about the Stanley Center: See here.

For more information about the iPSYCH consortium: See here.

For more information about the Lundbeck Foundation: See here.

‘A scored human protein–protein interaction network to catalyze genomic interpretation’ published in Nature Methods

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Today the Lage Lab published an article describing a quality controlled and scored human protein-protein interaction network to help functionally interpreting genomic data. Congratulations to Taibo Li, Heiko Horn and Kasper Lage.

 

Link to Nature Methods webpage: article.

Link to Broad Institute Snapshot on the article: Broad Institute Snapshot.

Link to press release from MGH: MGH press release.

For more information see here: InWeb_IM.